Neither Zyprexa Nor Risperdal Helped Psychotic Dementia in Elderly in Large Study: In a large 10-week DB PC study of patients with moderate-to-severe psychotic symptoms associated with dementia, those given olanzapine (N=204; 2.5 mg-10 mg/day), risperidone (N=196; 0.5 mg-2 mg/day) or placebo (N=94) had no significant treatment differences between groups after the 10 weeks. Overall discontinuation was olanzapine 16.2% vs. placebo 3.2% vs. risperidone 8.7%. Comparison of olanzapine and risperidone in the treatment of psychosis and associated behavioral disturbances in patients with dementia. Deberdt WG, et al. Brussels, Belgium. . Am J Geriatr Psychiatry. 2005 Aug;13(8):722-30.

Olanzapine Helps Some in DB: In a DB PC study of 206 demented patients with agitation/aggression or hallucinations, 5 mg (66%) worked better than 15 mg/d (43%) or placebo (35%). Street, Lilly, Arch Gen Psychiatry 2000;57:968

Haldol Helps Psychosis: In a DB PC study of 66 patients, 2-3 mg/d vs. 0.75 mg/day, the higher dose did better. Over 5 mg often causes severe EPS. v 0. Devanand, Am J Psychiatry 98;155:1512, NYSPI

Thomas E. Radecki, M.D., J.D.

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