Structural
Home Up Medicines Risk Factors Biochemistry Genetics Marijuana Other Psychoses Measurement Structural Other Issues Schizoaffective

 

While it is currently of little or no therapeutic value for schizophrenia, MRI and CT scans have found many abnormalities linked to schizophrenia.  I will start putting them on this page.

The severity of auditory hallucinations to be significantly correlated (P < 0.001) with volume loss in the left transverse temporal gyrus of Heschl (primary auditory cortex) and left (inferior) supramarginal gyrus, as well as middle/inferior right prefrontal gyri. This demonstrates a pattern of distributed structural abnormalities specific for auditory hallucinations and suggests hallucination-specific alterations in areas of a frontotemporal network for processing auditory information and language. Neuroanatomy of "hearing voices": a frontotemporal brain structural abnormality associated with auditory hallucinations in schizophrenia. Gaser C, Nenadic I, Volz HP, Buchel C, Sauer H. Cereb Cortex. 2004 Jan;14(1):91-6

Neurofibrillary tangles are more frequent among schizophrenic patients who received pharmacologic antipsychotic treatment. Curr Drug Targets CNS Neurol Disord. 2004 Dec;3(6):515-33.

Abnormal Lymphocytes in Schizophrenics Reported: In a study of 59 drug-free in-patients with paranoid schizophrenia and 31 normal controls, the frequency of small lymphocytes in schizophrenic patients was lower and that of large lymphocytes, LAL and atypical lymphocytes (lymphoblasts: LB) was higher than in controls (all p= < 0.01). The volume density (Vv) of mitochondria in LAL in individuals with schizophrenia was lower than in controls (p<0.05), correlated negatively with the frequency of LB, Vv and number of lysosomes in LB (all p<0.01) and with the psychosis severity (p<0.05). In schizophrenic patients a trend towards positive correlations between the frequency of LB and psychosis severity were found (p<0.07). The ultrastructure of lymphocytes in schizophrenia. Uranova N et al. Russian Academy of Medical Sciences, Moscow, Russia. . World J Biol Psychiatry 2007;8(1):30-7.